Increased Melanoma Risk in Parkinson Disease: A Prospective Clinicopathological Study
Identifieur interne : 001D04 ( Main/Exploration ); précédent : 001D03; suivant : 001D05Increased Melanoma Risk in Parkinson Disease: A Prospective Clinicopathological Study
Auteurs : John M. Bertoni [États-Unis] ; John Philip Arlette [Canada] ; Hubert H. Fernandez [États-Unis] ; Cheryl Fitzer-Attas [Israël] ; Karen Frei [États-Unis] ; Mohamed N. Hassan [États-Unis] ; Stuart H. Isaacson [États-Unis] ; Mark F. Lew [États-Unis] ; Eric Molho [États-Unis] ; William G. Ondo [États-Unis] ; Tania J. Phillips [États-Unis] ; Carlos Singer [États-Unis] ; James P. Sutton [États-Unis] ; John E. Jr Wolf [États-Unis]Source :
- Archives of neurology : (Chicago) [ 0003-9942 ] ; 2010.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Prospective.
English descriptors
Abstract
Objective: To evaluate the possible association of Parkinson disease (PD) and melanoma in North America. Design, Setting, and Patients: Thirty-one centers enrolled patients with idiopathic PD. At visit 1, a neurologist obtained a medical history. At visit 2, a dermatologist recorded melanoma risk factors, performed a whole-body examination, and performed a biopsy of lesions suggestive of melanoma for evaluation by a central dermatopathology laboratory. We compared overall prevalence of melanoma with prevalence calculated from the US Surveillance Epidemiology and End Results (SEER) cancer database and the American Academy of Dermatology skin cancer screening programs. Results: A total of 2106 patients (mean [SD] age, 68.6 [10.6] years; duration of PD, 7.1 [5.7] years) completed the study. Most (84.8%) had received levodopa. Dermatology examinations revealed 346 pigmented lesions; dermatopathological findings confirmed 20 in situ melanomas (0.9%) and 4 invasive melanomas (0.2%). In addition, histories revealed 68 prior melanomas (3.2%). Prevalence (5-year limited duration) of invasive malignant melanoma in the US cohort of patients with PD (n=1692) was 2.24-fold higher (95% confidence interval, 1.21-4.17) than expected in age- and sex-matched populations in the US SEER database. Age- or sex-adjusted relative risk of any melanoma for US patients was more than 7 times that expected from confirmed cases in American Academy of Dermatology skin cancer screening programs. Conclusions: Melanoma prevalence appears to be higher in patients with PD than in the general population. Despite difficulties in comparing other databases with this study population, the study supports increased melanoma screening in patients with PD.
Affiliations:
- Canada, Israël, États-Unis
- Alberta, Californie, Connecticut, Floride, Massachusetts, Texas, État de New York
- Calgary, Houston, Los Angeles
- Baylor College of Medicine, Université de Calgary, Université de Californie du Sud
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Lew</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Keck School of Medicine of University of Southern California</s1><s2>Los Angeles</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Molho, Eric" sort="Molho, Eric" uniqKey="Molho E" first="Eric" last="Molho">Eric Molho</name><affiliation wicri:level="2"><inist:fA14 i1="11"><s1>Movement Disorders Center, Albany Medical Center</s1><s2>Albany, New York</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Ondo, William G" sort="Ondo, William G" uniqKey="Ondo W" first="William G." last="Ondo">William G. Ondo</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Baylor College of Medicine</s1><s2>Houston, Texas</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Phillips, Tania J" sort="Phillips, Tania J" uniqKey="Phillips T" first="Tania J." last="Phillips">Tania J. Phillips</name><affiliation wicri:level="2"><inist:fA14 i1="13"><s1>Boston University School of Medicine</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Singer, Carlos" sort="Singer, Carlos" uniqKey="Singer C" first="Carlos" last="Singer">Carlos Singer</name><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>University of Miami School of Medicine</s1><s2>Miami, Florida</s2><s3>USA</s3><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Sutton, James P" sort="Sutton, James P" uniqKey="Sutton J" first="James P." last="Sutton">James P. 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Jr Wolf</name><affiliation wicri:level="4"><inist:fA14 i1="12"><s1>Departments of Dermatology, Baylor College of Medicine</s1><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university">Baylor College of Medicine</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">10-0157161</idno><date when="2010">2010</date><idno type="stanalyst">PASCAL 10-0157161 INIST</idno><idno type="RBID">Pascal:10-0157161</idno><idno type="wicri:Area/PascalFrancis/Corpus">000455</idno><idno type="wicri:Area/PascalFrancis/Curation">000822</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000341</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000341</idno><idno type="wicri:doubleKey">0003-9942:2010:Bertoni J:increased:melanoma:risk</idno><idno type="wicri:Area/Main/Merge">001E31</idno><idno type="wicri:Area/Main/Curation">001D04</idno><idno type="wicri:Area/Main/Exploration">001D04</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Increased Melanoma Risk in Parkinson Disease: A Prospective Clinicopathological Study</title><author><name sortKey="Bertoni, John M" sort="Bertoni, John M" uniqKey="Bertoni J" first="John M." last="Bertoni">John M. Bertoni</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurological Sciences, University of Nebraska Medical Center and Veterans Affairs Medical Center</s1><s2>Omaha</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Omaha</wicri:noRegion></affiliation></author><author><name sortKey="Arlette, John Philip" sort="Arlette, John Philip" uniqKey="Arlette J" first="John Philip" last="Arlette">John Philip Arlette</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Division of Surgical Oncology, University of Calgary</s1><s2>Calgary, Alberta</s2><s3>CAN</s3><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H." last="Fernandez">Hubert H. Fernandez</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Departments of Neurology, University of Florida</s1><s2>Gainesville</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Gainesville</wicri:noRegion></affiliation></author><author><name sortKey="Fitzer Attas, Cheryl" sort="Fitzer Attas, Cheryl" uniqKey="Fitzer Attas C" first="Cheryl" last="Fitzer-Attas">Cheryl Fitzer-Attas</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Teva Pharmaceutical Industries Ltd</s1><s2>Netanya</s2><s3>ISR</s3><sZ>4 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Teva Pharmaceutical Industries Ltd</wicri:noRegion></affiliation></author><author><name sortKey="Frei, Karen" sort="Frei, Karen" uniqKey="Frei K" first="Karen" last="Frei">Karen Frei</name><affiliation wicri:level="2"><inist:fA14 i1="09"><s1>The Parkinson's & Movement Disorders Institute, Fountain Valley</s1><s2>California</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hassan, Mohamed N" sort="Hassan, Mohamed N" uniqKey="Hassan M" first="Mohamed N." last="Hassan">Mohamed N. Hassan</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Hartford Hospital</s1><s2>Hartford, Connecticut</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Isaacson, Stuart H" sort="Isaacson, Stuart H" uniqKey="Isaacson S" first="Stuart H." last="Isaacson">Stuart H. Isaacson</name><affiliation wicri:level="2"><inist:fA14 i1="10"><s1>Parkinson's Disease and Movement Disorders Center</s1><s2>Boca Raton, Florida</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Lew, Mark F" sort="Lew, Mark F" uniqKey="Lew M" first="Mark F." last="Lew">Mark F. Lew</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Keck School of Medicine of University of Southern California</s1><s2>Los Angeles</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Molho, Eric" sort="Molho, Eric" uniqKey="Molho E" first="Eric" last="Molho">Eric Molho</name><affiliation wicri:level="2"><inist:fA14 i1="11"><s1>Movement Disorders Center, Albany Medical Center</s1><s2>Albany, New York</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Ondo, William G" sort="Ondo, William G" uniqKey="Ondo W" first="William G." last="Ondo">William G. Ondo</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Baylor College of Medicine</s1><s2>Houston, Texas</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Phillips, Tania J" sort="Phillips, Tania J" uniqKey="Phillips T" first="Tania J." last="Phillips">Tania J. Phillips</name><affiliation wicri:level="2"><inist:fA14 i1="13"><s1>Boston University School of Medicine</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Singer, Carlos" sort="Singer, Carlos" uniqKey="Singer C" first="Carlos" last="Singer">Carlos Singer</name><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>University of Miami School of Medicine</s1><s2>Miami, Florida</s2><s3>USA</s3><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Sutton, James P" sort="Sutton, James P" uniqKey="Sutton J" first="James P." last="Sutton">James P. Sutton</name><affiliation wicri:level="2"><inist:fA14 i1="14"><s1>Pacific Neuroscience Medical Group</s1><s2>Oxnard, California</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Wolf, John E Jr" sort="Wolf, John E Jr" uniqKey="Wolf J" first="John E. Jr" last="Wolf">John E. Jr Wolf</name><affiliation wicri:level="4"><inist:fA14 i1="12"><s1>Departments of Dermatology, Baylor College of Medicine</s1><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university">Baylor College of Medicine</orgName></affiliation></author></analytic><series><title level="j" type="main">Archives of neurology : (Chicago)</title><title level="j" type="abbreviated">Arch. neurol. : (Chic.)</title><idno type="ISSN">0003-9942</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Archives of neurology : (Chicago)</title><title level="j" type="abbreviated">Arch. neurol. : (Chic.)</title><idno type="ISSN">0003-9942</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Malignant melanoma</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Prospective</term><term>Risk factor</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Mélanome malin</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Facteur risque</term><term>Prospective</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Prospective</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: To evaluate the possible association of Parkinson disease (PD) and melanoma in North America. Design, Setting, and Patients: Thirty-one centers enrolled patients with idiopathic PD. At visit 1, a neurologist obtained a medical history. At visit 2, a dermatologist recorded melanoma risk factors, performed a whole-body examination, and performed a biopsy of lesions suggestive of melanoma for evaluation by a central dermatopathology laboratory. We compared overall prevalence of melanoma with prevalence calculated from the US Surveillance Epidemiology and End Results (SEER) cancer database and the American Academy of Dermatology skin cancer screening programs. Results: A total of 2106 patients (mean [SD] age, 68.6 [10.6] years; duration of PD, 7.1 [5.7] years) completed the study. Most (84.8%) had received levodopa. Dermatology examinations revealed 346 pigmented lesions; dermatopathological findings confirmed 20 in situ melanomas (0.9%) and 4 invasive melanomas (0.2%). In addition, histories revealed 68 prior melanomas (3.2%). Prevalence (5-year limited duration) of invasive malignant melanoma in the US cohort of patients with PD (n=1692) was 2.24-fold higher (95% confidence interval, 1.21-4.17) than expected in age- and sex-matched populations in the US SEER database. Age- or sex-adjusted relative risk of any melanoma for US patients was more than 7 times that expected from confirmed cases in American Academy of Dermatology skin cancer screening programs. Conclusions: Melanoma prevalence appears to be higher in patients with PD than in the general population. Despite difficulties in comparing other databases with this study population, the study supports increased melanoma screening in patients with PD.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Israël</li><li>États-Unis</li></country><region><li>Alberta</li><li>Californie</li><li>Connecticut</li><li>Floride</li><li>Massachusetts</li><li>Texas</li><li>État de New York</li></region><settlement><li>Calgary</li><li>Houston</li><li>Los Angeles</li></settlement><orgName><li>Baylor College of Medicine</li><li>Université de Calgary</li><li>Université de Californie du Sud</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Bertoni, John M" sort="Bertoni, John M" uniqKey="Bertoni J" first="John M." last="Bertoni">John M. Bertoni</name></noRegion><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H." last="Fernandez">Hubert H. Fernandez</name><name sortKey="Frei, Karen" sort="Frei, Karen" uniqKey="Frei K" first="Karen" last="Frei">Karen Frei</name><name sortKey="Hassan, Mohamed N" sort="Hassan, Mohamed N" uniqKey="Hassan M" first="Mohamed N." last="Hassan">Mohamed N. Hassan</name><name sortKey="Isaacson, Stuart H" sort="Isaacson, Stuart H" uniqKey="Isaacson S" first="Stuart H." last="Isaacson">Stuart H. Isaacson</name><name sortKey="Lew, Mark F" sort="Lew, Mark F" uniqKey="Lew M" first="Mark F." last="Lew">Mark F. Lew</name><name sortKey="Molho, Eric" sort="Molho, Eric" uniqKey="Molho E" first="Eric" last="Molho">Eric Molho</name><name sortKey="Ondo, William G" sort="Ondo, William G" uniqKey="Ondo W" first="William G." last="Ondo">William G. Ondo</name><name sortKey="Phillips, Tania J" sort="Phillips, Tania J" uniqKey="Phillips T" first="Tania J." last="Phillips">Tania J. Phillips</name><name sortKey="Singer, Carlos" sort="Singer, Carlos" uniqKey="Singer C" first="Carlos" last="Singer">Carlos Singer</name><name sortKey="Sutton, James P" sort="Sutton, James P" uniqKey="Sutton J" first="James P." last="Sutton">James P. Sutton</name><name sortKey="Wolf, John E Jr" sort="Wolf, John E Jr" uniqKey="Wolf J" first="John E. Jr" last="Wolf">John E. Jr Wolf</name></country><country name="Canada"><region name="Alberta"><name sortKey="Arlette, John Philip" sort="Arlette, John Philip" uniqKey="Arlette J" first="John Philip" last="Arlette">John Philip Arlette</name></region></country><country name="Israël"><noRegion><name sortKey="Fitzer Attas, Cheryl" sort="Fitzer Attas, Cheryl" uniqKey="Fitzer Attas C" first="Cheryl" last="Fitzer-Attas">Cheryl Fitzer-Attas</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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